… To examine the role of SIRT1 in regulating MMP13 in vivo we explored the expression of
this protease in an animal model, Sirt1 2/2 mice (29). We assessed 1-wk-old Sirt1 …

… group family that regulates gene expression by inducing … , we hypothesized that LEF1
regulated the progression of … f RNF121 expression in LEF1-altered expressing chondrocytes was …

… SIRT1 directly represses LEF1 gene expression by binding its … costal and articular chondrocytes
from ATC Lef1 fl/fl and Lef1 fl/… up-regulated in the Lef1-null chondrocytes and previously …

… the chondrocyte receives and integrates into gene expression … Of the four family members
(TCF1, TCF3, TCF4, and LEF1), … evidence that chondrocyte hypertrophy is regulated by many …

… Gene expression levels were calculated by fragments per kilobase of exon per million fragments
mapped (FPKM). The expression level of each gene … TCF7/LEF1) were down-regulated (…

… chondrocytes. The object of this study was to investigate whether microRNA-449a regulates
expression of SIRT1, which inhibits expression … 1 (LEF-1), which is a critical gene known and …

… show expression of Lef-1 in proliferative chondrocytes) and … expression of Lef-1 in mineralized
hypertrophic chondrocytes… by regulating the number of proliferating chondrocytes and the …

… For the examination of gene expression, RNA was extracted from … regulates MMP-13
expression in human OA chondrocytes, through the repression of the transcription activity of LEF1 …

… chondrocytes stimulated with IL-1β, β-catenin/LEF1 together with RelA formed a transcriptional
complex through gene looping in the Mmp13 genomic locus to regulate gene … NF-kappaB …

… and activation of the NF-kappaB pathway by increasing the … the p65 protein from the cytoplasm
to the nucleus in chondrocytes [… The relative β-catenin mRNA expression in the OA group (…